[Survival analysis of 229 patients with advanced squamous cell carcinoma of the oral tongue].

نویسندگان

  • An-Kui Yang
  • Tian-Run Liu
  • Fu-Jin Chen
  • Xiu-Fang Ma
  • Zhu-Ming Guo
  • Ming Song
  • Qiu-Li Li
  • Zong-Yuan Zeng
چکیده

BACKGROUND & OBJECTIVE Patients with advanced squamous cell carcinoma (SCC) of the oral tongue have poor prognosis. This study was to analyze the most important factors affecting the prognosis of the patients with advanced (stage III and IV) SCC of the oral tongue. METHODS Complete clinical and follow-up data of 229 patients with pathologically confirmed advanced SCC of the oral tongue, initially treated at Sun Yat-sen University Cancer Center were retrospectively analyzed. Survival analysis was performed using the Kaplan-Meier analysis, comparison among groups was analyzed using log-rank test, and multivariate analysis was conducted using the Cox proportional hazard model. Independent risk factors were deducted. The risk function was established and evaluated. RESULTS The mean survival time of the 229 patients was 80.33 months, with the two-and five-year survival rates of 50.66% and 37.99%, respectively. Univariate analysis showed that age, tongue base invasion, cervical lymphatic metastasis, stage, surgical treatment, recurrence and residual tumor were risk factors affecting prognosis (P<0.05). Multivariate analysis indicated that tumour invasion across the midline, cervical lymphatic metastases, surgical treatment, recurrence and residual tumor were independent factors for prognosis. Moreover, the risk function effectively predicted the prognosis. CONCLUSIONS The prognosis of patients with advanced SCC of the oral tongue is poor. Tumour invasion across the midline, cervical lymphatic metastasis, surgical treatment, recurrence, and residual tumor are independent factors affecting the prognosis.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Tongue Squamous Cell Carcinoma: A Clinical Study

  Background and Objectives: Squamous cell carcinoma of the tongue (SCCOT) is the most common malignant neoplasm in oral cavity. At the time of the diagnosis of SCCOT regional metastases with a high mortality rate are common, which is due to the extensive lymphatic system drainage of the tongue. Although the level of healthcare has significantly improved, the survival rate is still low with an...

متن کامل

Serum Level of Interleukin-6 in Patients with Oral Tongue Squamous cell Carcinoma

Introduction: The clinical outcome of patients with squamous cell carcinoma (SCC) located in the head and neck has remained poor despite ongoing advances in diagnosis and management. Interleukin-6(IL-6) is a multi-functional cytokine that plays an important role in the process of cell differentiation and is increased in several malignancies. The aim of this study was to investigate the serum le...

متن کامل

The Prevalence of Human Papilloma Virus in Squamous Cell Carcinoma of Oral Tongue

Background and objective:  Oral tongue Squamous Cell carcinoma (SCC) commonly involves males between the sixth to eighth decades of life. Major risk factors are tobacco usage and alcohol consumption. The increasing number of patients developing oral tongue cancer without these well-known risk factors suggests that a viral infection, such as Human Papil...

متن کامل

Tongue squamous cell carcinoma in a patient with systemic sclerosis: A case report

Objective: Systemic sclerosis (SS) is a chronic autoimmune disease of connective tissue, which involves skin and internal organs, and results in collagen deposition and fibroblasts activation. Studies have reported a higher risk of malignancy in patients with progressive systemic sclerosis (PSS).The aim of this study is to report a case of tongue squamous cell carcinoma (SCC) in a patient with ...

متن کامل

Correlation between p33ING1b Cytoplasmic Transfer and Lymph Node Metastasis in Oral Squamous Cell Carcinoma

Background: Oral squamous cell carcinoma is the sixth most common malignancy in the world today.  ING1b/p33 is a newly-discovered tumor suppressor which enhances p53 activity. Transfer of p33 protein from nucleus to cytoplasmic compartment has been previously reported in leukemias. The objective of this study was to determine the correlation between p33ing1b cytoplasmic transfer and lymph node ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Ai zheng = Aizheng = Chinese journal of cancer

دوره 27 12  شماره 

صفحات  -

تاریخ انتشار 2008